Tysabri (Natalizumab) Infusion Cost in 2026, and How to Lower It
A single Tysabri (natalizumab) infusion is commonly billed at $6,000 to $11,000 or more, with a hospital outpatient department at the high end and a certified infusion center much less for the exact same drug and dose. The two biggest levers are where you get infused and switching to a biosimilar, and if you qualify, the maker can help with the cost.
- Site of care is a major driver. Tysabri is given at sites certified under the TOUCH risk-management program, and a hospital outpatient department is often billed 2 to 3 times more than a certified freestanding infusion center for the same drug.
- A natalizumab biosimilar (Tyruko, natalizumab-sztn) is available and costs less. Whether one is right for you is a decision for you and your prescriber. A subcutaneous form of natalizumab also exists as a prescriber option.
- If you are uninsured or your plan will not cover it, Biogen runs patient assistance and copay support (Biogen Support Services) for those who qualify. On Medicare, use a charity copay fund instead.
What a Tysabri Infusion Costs
Tysabri is given as a fixed 300 mg IV dose every 4 weeks and is billed under J-code J2323. It must be administered at a site certified under the TOUCH risk-management program. These are national estimates; your bill depends on site and plan.
| Where you get it | Typical billed cost per infusion |
|---|---|
| Hospital outpatient department (TOUCH certified) | ~$9,000 to $16,000+ |
| Certified infusion center | ~$6,000 to $11,000 |
| Biosimilar (Tyruko, natalizumab-sztn) | less |
| With manufacturer assistance | reduced, if you qualify |
Tysabri is given every 4 weeks, so annual cost adds up quickly, which is why the site-of-care and biosimilar levers matter so much.
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How to Lower the Cost
Ask to move the infusion to a certified lower-cost site
Tysabri has to be given at a site certified under the TOUCH program, but many freestanding infusion centers are certified and cost far less than a hospital. If you are stable, ask your prescriber whether your infusions can move to a certified lower-cost site. It does not change the medicine.
Ask about the biosimilar or the subcutaneous form
Tyruko (natalizumab-sztn) is an FDA-approved biosimilar to Tysabri that costs less, and a subcutaneous form of natalizumab also exists. Whether either fits your treatment is a decision for you and your prescriber, but both are worth raising.
Use the right assistance for your situation
Uninsured or not covered? Biogen Support Services offers patient assistance that may help with the cost if you qualify. Commercially insured? Biogen copay support can cut your coinsurance. On Medicare? Use a charity fund like the PAN or HealthWell Foundation. Our help paying for medication tool and our guide to patient assistance programs point you to the right one.
Check the bill for errors, especially the J-code units
Tysabri is billed under J2323, and a units or facility-fee error can multiply the charge. CareRoute Bill Defense checks the units, drug wastage, facility fees, and network status, and disputes errors, with no fee unless we save you money.
Frequently Asked Questions
How much does a Tysabri infusion cost?
A single Tysabri (natalizumab) infusion is commonly billed at about $6,000 to $11,000 or more, and can run higher at a hospital because of the facility fee. The same 300 mg drug and dose is often billed well below that at a certified freestanding infusion center. Tysabri is given every 4 weeks.
Why is my infusion so much more expensive at the hospital?
Hospitals add a facility fee and negotiate higher drug rates, so the identical natalizumab infusion is routinely billed 2 to 3 times more in a hospital outpatient department than at a certified freestanding infusion center. Tysabri must be given at a TOUCH-certified site, but many infusion centers are certified. If you are stable, ask your prescriber whether the infusion can move to a lower-cost certified site.
Is a biosimilar as good as Tysabri, and is it cheaper?
Tyruko (natalizumab-sztn) is FDA-approved as a biosimilar to Tysabri, highly similar with no clinically meaningful differences, and it generally costs less. A subcutaneous form of natalizumab also exists. Whether either is right for you is a decision between you and your prescriber.
Can I get help paying for Tysabri?
If you are uninsured, or insured but your plan will not cover it, Biogen Support Services offers patient assistance that may help with the cost if you qualify. Commercially insured patients can use Biogen copay support, and Medicare patients can use independent charity funds. Our help-paying-for-medication tool points you to the program that fits your situation.
Will my insurance out-of-pocket maximum cap what I pay?
For in-network, covered care, yes. Once you hit your plan’s out-of-pocket maximum, it covers 100% of remaining in-network covered costs for the year. But an out-of-network site or provider can bill amounts that do not count toward that cap, which is why confirming network status of every party matters.
Related
Sources
- CMS Average Sales Price (ASP) drug pricing files (J2323 natalizumab)
- FDA (Tysabri and Tyruko natalizumab-sztn biosimilar approval; TOUCH risk-management program)
- Health Care Cost Institute and AHA (hospital facility fees and site-of-care differentials)
- Biogen Support Services (patient assistance and copay support eligibility)
Prices are national estimates for 2026 and vary widely by site and plan. Any change of drug or infusion site is a decision for you and your prescriber. This page is educational and is not medical or financial advice. Last updated August 2026.