Ocrevus (Ocrelizumab) Cost in 2026, and How to Lower It
Ocrevus (ocrelizumab) for multiple sclerosis has a list price of roughly $16,000 to $20,000 per infusion, given every six months, so it runs about $65,000 a year before insurance. Because it is a Genentech drug, if you qualify the Genentech Patient Foundation can provide it free, and site of care plus charity funds can cut what you actually pay.
- Ocrevus is 600 mg IV every 6 months (after two initial 300 mg doses two weeks apart), billed under J-code J2350, so it is a large, twice-a-year charge.
- Genentech makes Ocrevus, so uninsured or underinsured patients under an income limit may get it free through the Genentech Patient Foundation, which does not require citizenship information.
- For insured patients, the biggest out-of-pocket relief comes from a Genentech copay card (commercial plans) or an MS charity fund (Medicare), plus choosing a lower-cost infusion site.
What Ocrevus Costs
These are national list-price estimates. What you personally owe depends on your insurance, your out-of-pocket maximum, and any assistance you use.
| What | Typical amount |
|---|---|
| Per 600 mg infusion (drug) | ~$16,000 to $20,000 |
| Per year (two doses) | ~$65,000 |
| Your out-of-pocket, insured | up to your OOP max |
| With the Genentech Patient Foundation | as low as $0 (drug) |
A subcutaneous form (Ocrevus Zunovo) given as a roughly 10-minute injection is also available and avoids the IV infusion chair time and facility fee. Ask your prescriber.
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How to Lower the Cost
Ask if the maker will provide it free
If you are uninsured, or insured but your plan will not cover it, and your income is under the limit, the Genentech Patient Foundation (1-888-941-3331) can provide Ocrevus free. Your prescriber submits the request and the drug ships to your infusion site. It does not require citizenship information.
Use a copay card or an MS charity fund
With commercial insurance, a Genentech copay card can bring your coinsurance close to $0 up to an annual max. On Medicare, use an independent MS fund (PAN, HealthWell, Good Days) instead, since copay cards are not allowed. Our help paying for medication tool routes you to the right one.
Choose a lower-cost infusion site
A standalone infusion center or doctor’s office avoids the hospital facility fee. Even when insurance covers the drug, a lower site cost helps you reach your out-of-pocket maximum on less, and lowers what your plan pays.
Have a surprise bill reviewed
On a drug this expensive, a coding error, a wrong site, or an out-of-network provider can create a large bill you should not owe. CareRoute Bill Defense reviews it and disputes errors, with no fee unless we save you money.
Frequently Asked Questions
How much does Ocrevus cost per year?
Ocrevus has a list price of roughly $16,000 to $20,000 per 600 mg infusion, given every six months, so about $65,000 a year before insurance. Insured patients usually pay far less, often only up to their annual out-of-pocket maximum, and free-drug and charity programs can lower it further.
Can I get Ocrevus for free?
Possibly. Genentech makes Ocrevus, and the Genentech Patient Foundation provides it free to uninsured or underinsured patients under an income limit (generally up to about 500% of the federal poverty level, with hardship reviewed higher). Your prescriber submits the request, the drug ships to your infusion center, and the Foundation does not require citizenship information.
I have insurance. Why am I still facing a big bill?
Because Ocrevus is so expensive, your share of even one dose can equal your entire annual out-of-pocket maximum. The good news is that once you hit that maximum, in-network covered care is paid at 100% for the rest of the year. A copay card (commercial) or a charity fund (Medicare) can cover much of that share.
Is there a cheaper or easier form of Ocrevus?
A subcutaneous form (Ocrevus Zunovo) is given as a roughly 10-minute injection twice a year instead of a long IV, which can avoid infusion chair time and the facility fee. Whether it is right for you is a decision for your prescriber. There is no biosimilar to Ocrevus yet.
Does where I get the infusion change the cost?
Yes. A hospital outpatient department adds a facility fee on top of the drug, so a standalone infusion center or a doctor’s office is cheaper for the same infusion. Even when insurance covers the drug, a lower site cost reduces what your plan pays and can help you reach your out-of-pocket maximum on less.
Related
Sources
- CMS Average Sales Price (ASP) drug pricing files (J2350 ocrelizumab)
- Genentech Patient Foundation (free-drug eligibility and process)
- Genentech Ocrevus prescribing and dosing information
- PAN Foundation and HealthWell Foundation (MS copay funds)
Prices are national list-price estimates for 2026 and vary by site and plan. Any change of drug, form, or infusion site is a decision for you and your prescriber. This page is educational and is not medical or financial advice. Last updated August 2026.