How Much Does an Endometrial Biopsy Cost in 2026?
In a doctor's office, an endometrial biopsy typically costs $150 to $800 self-pay (the procedure plus the separately billed pathology), and can reach $1,000 to $1,500+ in a hospital outpatient department or if a hysteroscopy is added. With insurance, most people pay about $50 to $300 out of pocket.
- An endometrial biopsy (CPT 58100) is a quick in-office diagnostic procedure, not surgery. The biopsy itself is cheap, often around $100 to $250 for the procedure fee alone.
- Two add-ons drive most of the surprise cost: the pathology (lab) charge on the tissue sample, which is almost always billed separately, and a facility fee if the biopsy is done in a hospital outpatient department.
- The exact same CPT code can cost several times more in a hospital outpatient setting than in a doctor's office, so where you have it done matters as much as anything else.
Endometrial Biopsy Cost by Setting
Cash / self-pay price ranges for the same procedure (CPT 58100). Where it is done is the biggest factor. Pathology on the tissue sample is usually billed separately on top.
| Setting | Cash price |
|---|---|
| Doctor's office or clinic (procedure only) | $100 to $250 |
| Office biopsy plus pathology (bundled) | $150 to $800 |
| Hospital outpatient department | $800 to $1,500+ |
| With hysteroscopy added (D&C / scope) | $1,500 to $3,000+ |
Lowest price: Having the biopsy in your gynecologist's office or a clinic, and asking for a cash price that includes (or at least discloses) the pathology charge. A plain office endometrial biopsy needs no operating room and no anesthesia.
Want to know what your endometrial biopsy should cost you?
Costs vary substantially by procedure, location, facility, and insurance. Get a personalized estimate based on your situation.
Already have a bill? Send it to CareRoute and we will work to reduce it. 64% of cases reduced.
What Makes Up the Bill
For a standard office endometrial biopsy, the total is usually small and splits across just two or three line items:
There is no operating room and no anesthesia for a standard office biopsy, so those surgical line items do not apply. Light sedation shows up only if a hysteroscopy is added, which is a separate, larger procedure. The two items that catch people off guard are the pathology charge (a separate bill, often from a different company) and, in a hospital outpatient setting, the facility fee, which can be larger than the biopsy itself.
With vs. Without Insurance
Without insurance (self-pay)
$150 to $800
In a doctor's office, including the separately billed pathology. Ask for the cash or prompt-pay price up front, and ask whether it covers the lab reading. A hospital outpatient department or an added hysteroscopy can push the total to $1,500 or more.
With insurance (out of pocket)
$50 to $300
With commercial insurance, a medically necessary in-network endometrial biopsy usually leaves you owing a copay, or your deductible plus coinsurance up to your annual out-of-pocket maximum. Confirm the office and the pathology lab are both in-network to avoid a surprise lab bill. Medicare beneficiaries owe about 20% coinsurance after the Part B deductible unless a Medigap plan covers it.
Prices vary widely by region and by setting. Within a single metro, the same endometrial biopsy code can cost several times more in a hospital outpatient department than in a physician's office, so where you have it done, and getting the pathology charge quoted up front, matters more than your region alone.
How to Pay Less
Have it done in a doctor's office, not a hospital
A standard endometrial biopsy is the same quick procedure in your gynecologist's office as in a hospital outpatient department, but the office avoids a facility fee that can cost several times the biopsy itself. If you have a choice of where to go, the office or clinic is almost always the lowest-cost setting.
Ask about the pathology charge before your visit
The tissue sample is sent to a lab and billed separately, often by a different company, so a quoted procedure price may not include it. Ask which lab is used, whether it is in your network, and what the pathology reading will cost, so you are not surprised by a second bill.
Request an all-in cash price in writing
If you are uninsured, ask for a single cash price that bundles the office procedure and the pathology so there are no surprise add-ons. Cash-pay marketplaces often list bundled endometrial biopsy prices, and offices commonly discount for payment up front.
Compare prices using price-transparency files
Federal rules require hospitals to post machine-readable cash prices, and many clinics will quote one on request. Reported prices for the same biopsy code range widely, so a quick check of two or three local options can save you the cost of a facility fee.
Check hospital charity care, or get the bill reduced
Uninsured or lower income? Many hospitals offer free or discounted care. Use the charity care finder to see if you qualify nearby. Already billed for a biopsy, pathology, or facility fee that looks too high? CareRoute Bill Defense reviews and negotiates it down, with no fee unless we save you money.
Frequently Asked Questions
Does insurance cover an endometrial biopsy?
Yes. When it is medically necessary (for example, abnormal or postmenopausal uterine bleeding, a thickened uterine lining, or follow-up of an abnormal ultrasound), an endometrial biopsy is covered by essentially all commercial plans, Medicare, and Medicaid. Your out-of-pocket is your copay or your deductible plus coinsurance, capped by your plan's annual out-of-pocket maximum, commonly $50 to $300. Note that the pathology (lab) reading of the tissue sample is usually billed separately, so you may see more than one charge for a single visit.
Why did I get a separate pathology bill after my endometrial biopsy?
The tissue sample taken during the biopsy is sent to a lab, where a pathologist examines it and writes a report. That lab work is billed separately from the office procedure fee, often by a different company, so a single biopsy visit can generate two or three charges: the procedure, the pathology, and (if done in a hospital outpatient department) a facility fee. The pathology charge is a common surprise, so ask up front whether it is included in any quoted price.
Why is an endometrial biopsy so much more expensive at a hospital?
An endometrial biopsy is the same quick in-office procedure (CPT 58100) wherever it is done, but a hospital outpatient department adds a facility fee on top of the physician charge. That facility fee can make the same biopsy cost several times more than it would in a doctor's office. If you have a choice, having it done in a physician's office or a clinic is usually the lowest-cost setting.
What is the cheapest way to get an endometrial biopsy?
Having the biopsy done in your gynecologist's office or a clinic, rather than a hospital outpatient department, is usually the least expensive because it avoids a facility fee. Ask for a cash or prompt-pay price, and ask specifically whether it includes the pathology (lab) charge. A standard office endometrial biopsy needs no operating room and no anesthesia, which keeps it cheap; only an added hysteroscopy with light sedation raises the cost.
How much does Medicare pay for an endometrial biopsy (CPT 58100)?
Under the 2026 Medicare Physician Fee Schedule, the approved amount for an endometrial biopsy (CPT 58100) is about $98 when it is done in a doctor's office (the non-facility rate) and about $55 when it is done in a facility such as a hospital outpatient department, where the facility bills its own fee on top. You are generally responsible for about 20% coinsurance after the Part B deductible unless a Medigap plan covers it, and the pathology reading is billed and paid separately.
More Cost Guides
Sources
- CMS 2026 Physician Fee Schedule (CPT 58100, $33.4009 conversion factor), national payment from total RVUs: about $98 non-facility (office) and about $55 facility
- MDsave bundled and cash pricing for endometrial biopsy (office and all-in)
- Hospital price-transparency (machine-readable file) cash rates for CPT 58100
- Healthcare Bluebook and FAIR Health fair-price data for endometrial biopsy
- GoodRx and clinic self-pay rate sheets for endometrial biopsy and pathology
Prices are national estimates for 2026 and vary by location, setting, provider, and your specific plan. Last updated October 2, 2026.